When WM transforms
In rare cases, Waldenstrom's macroglobulinaemia can change (or transform) into a faster-growing, or high-grade, form of lymphoma. It’s important to remember that WM doesn’t transform in most people. However, it is good to be aware of the symptoms so that you can get a quick diagnosis and receive treatment.
What is transformation?
Waldenstrom's macroglobulinaemia is known as an ‘indolent’ or ‘low-grade’ form of lymphoma. This means that it is slow growing. Waldenstrom's macroglobulinaemia is one of many different types of low-grade lymphomas which may not need treatment for some time, if at all. If you do require treatment, most people have periods of remission (when cancer cells can’t be found) and some will later relapse (when cancer cells start growing again).
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High-grade lymphomas on the other hand are faster-growing and might be referred to as ‘aggressive’ lymphomas because of this. High grade lymphomas often need treatment straightaway. Most people who are diagnosed with a high-grade lymphoma are treated successfully and stay in remission.
Very rarely, a low-grade lymphoma can change (or transform) into a high-grade lymphoma, meaning the cells change from slower-growing into faster-growing ones. In most cases, WM will transform into a type of high-grade lymphoma called diffuse large B-cell lymphoma (DLBCL), but it can transform into other types of high-grade lymphoma too.
Transformation can happen at any time – it might be found at diagnosis with WM, or it may happen many years afterwards.
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If you’re diagnosed with a high-grade lymphoma, it doesn’t mean your WM has disappeared but that you have aggressive lymphoma cells in your body alongside your low-grade WM.
Getting support
It’s important to remember that Waldenstrom's macroglobulinaemia transforms only in very rare cases, and your healthcare team will be checking you at appointments for any sign that your WM is changing.
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If you are worried for any reason, you should always contact your healthcare team who will be able help and advise you.
Being diagnosed with a high-grade lymphoma might come as a shock and cause anxiety about your future. Keep an open line with your clinician and clinical nurse specialist (CNS), who will be able to help you find the support you need.
Whether you’re worried about symptoms, or want to talk through any questions, you can contact WMUK anytime by email or phone: 0300 303 5870.
