The UK charity for Waldenstrom’s macroglobulinaemia – a rare type of blood cancer
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Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies (ELM-1)

Understanding the best doses for Odronextamb in patients with a type of protein on their B-cells
Main Aims

Some people with non-Hodgkin Lymphoma have a protein called CD20 on their B-cells. This study is focussed on a type of treatment that targets this protein, giving researchers insight into what the right dosage is, and looking at different ways of giving the drug.

This study closed on 21st August 2025.

Recruitment Criteria

• Confirmed WM diagnosis; and are documented as having the CD20 protein
• Previously been treated with a minimum of two lines of systemic therapy, including at least one line of anti-CD-20 treatment
• No further standard options remaining

Recruitment status: closed
Sponsor: Regeneron Pharmaceuticals
Expected to end: 30/09/2025
Phases: