The UK charity for WM & LPL – a rare type of blood cancer

Support Line: 0300 373 8500
LPL Fact Sheet

non-IgM LPL (Lymphoplasmacytic Lymphoma) Fact Sheet

April 2, 2026

Our guide for those diagnosed with LPL

If you’ve been diagnosed with Lymphoplasmacytic Lymphoma (LPL), this fact sheet is a straightforward starting point for making sense of your diagnosis.

Written in plain language, it explains what LPL is, how it differs from WM, and why 19 out of 20 people with LPL are diagnosed with WM specifically. It covers common symptoms,  from fatigue and swollen glands to hyperviscosity, and gives a clear overview of the treatment options available, including chemotherapy, targeted therapies such as BTK inhibitors, and what active monitoring actually means in practice.

This guide is for anyone newly diagnosed, as well as family members and carers trying to understand what to expect. It won’t answer every question, but it will help you go into conversations with your medical team better prepared.

For personalised support, call our helpline on 0300 373 8500 or email support@wmuk.org.uk.

Related Documents

WMUK Impact Report 2024–25
How we reached, supported and empowered more people living with WM and LPL than ever before.
non-IgM LPL Fact Sheet
Our guide for those diagnosed with LPL
WMUK Brochure
Find out all about WMUK